262209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4014866..4015474 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag PALA37_RS18645 Protein ID WP_016263850.1
Coordinates 4015127..4015474 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA37_RS18640 Protein ID WP_003114155.1
Coordinates 4014866..4015117 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS18620 (PALA37_03686) 4010504..4010854 + 351 WP_003159569.1 DUF2523 family protein -
PALA37_RS18625 (PALA37_03687) 4010856..4012118 + 1263 WP_124131951.1 zonular occludens toxin domain-containing protein -
PALA37_RS18630 (PALA37_03689) 4012377..4013669 + 1293 WP_270132557.1 hypothetical protein -
PALA37_RS18635 (PALA37_03690) 4013669..4014652 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PALA37_RS18640 4014866..4015117 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA37_RS18645 (PALA37_03691) 4015127..4015474 + 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA37_RS18655 (PALA37_03693) 4015801..4016703 - 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA37_RS18660 (PALA37_03694) 4017155..4017892 - 738 WP_023127195.1 murein L,D-transpeptidase catalytic domain family protein -
PALA37_RS18665 (PALA37_03695) 4017972..4019015 - 1044 WP_003134392.1 L,D-transpeptidase -
PALA37_RS18670 (PALA37_03696) 4019151..4019843 - 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
PALA37_RS18675 (PALA37_03697) 4019843..4020115 - 273 WP_021264275.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3990223..4015474 25251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T262209 WP_016263850.1 NZ_CP109850:4015127-4015474 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT262209 WP_003114155.1 NZ_CP109850:4014866-4015117 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References