262203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5330238..5330846 Replicon chromosome
Accession NZ_CP109849
Organism Pseudomonas aeruginosa strain PALA34

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag PALA34_RS25070 Protein ID WP_003123043.1
Coordinates 5330238..5330585 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA34_RS25075 Protein ID WP_003114155.1
Coordinates 5330595..5330846 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA34_RS25040 (PALA34_04951) 5325597..5325869 + 273 WP_016851967.1 cysteine-rich CWC family protein -
PALA34_RS25045 (PALA34_04952) 5325869..5326561 + 693 WP_016851968.1 16S rRNA pseudouridine(516) synthase -
PALA34_RS25050 (PALA34_04953) 5326697..5327740 + 1044 WP_003098363.1 L,D-transpeptidase -
PALA34_RS25055 (PALA34_04954) 5327820..5328557 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PALA34_RS25060 (PALA34_04955) 5329009..5329911 + 903 WP_014603238.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA34_RS25070 (PALA34_04957) 5330238..5330585 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA34_RS25075 5330595..5330846 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA34_RS25080 (PALA34_04958) 5331060..5332043 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
PALA34_RS25085 (PALA34_04959) 5332043..5333335 - 1293 WP_003115206.1 hypothetical protein -
PALA34_RS25090 (PALA34_04961) 5333594..5334856 - 1263 WP_023093179.1 zonular occludens toxin domain-containing protein -
PALA34_RS25095 (PALA34_04962) 5334858..5335208 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5330238..5352079 21841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T262203 WP_003123043.1 NZ_CP109849:c5330585-5330238 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT262203 WP_003114155.1 NZ_CP109849:c5330846-5330595 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References