Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4942145..4942731 Replicon chromosome
Accession NZ_CP109849
Organism Pseudomonas aeruginosa strain PALA34

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA34_RS23120 Protein ID WP_003120987.1
Coordinates 4942432..4942731 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA34_RS23115 Protein ID WP_003448662.1
Coordinates 4942145..4942435 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA34_RS23095 (PALA34_04567) 4937296..4937505 + 210 WP_003105733.1 cold-shock protein -
PALA34_RS23100 (PALA34_04568) 4937727..4939616 + 1890 WP_016851610.1 hypothetical protein -
PALA34_RS23105 (PALA34_04569) 4939613..4941589 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
PALA34_RS23110 4941730..4942074 + 345 WP_016851612.1 hypothetical protein -
PALA34_RS23115 (PALA34_04570) 4942145..4942435 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA34_RS23120 (PALA34_04571) 4942432..4942731 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA34_RS23125 (PALA34_04572) 4942933..4944057 + 1125 WP_012076859.1 TcpQ domain-containing protein -
PALA34_RS23130 (PALA34_04573) 4944057..4945766 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PALA34_RS23135 (PALA34_04574) 4945770..4947095 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PALA34_RS23140 (PALA34_04575) 4947085..4947618 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4916021..5018002 101981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T262202 WP_003120987.1 NZ_CP109849:c4942731-4942432 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT262202 WP_003448662.1 NZ_CP109849:c4942435-4942145 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References