Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4574029..4575039 Replicon chromosome
Accession NZ_CP109846
Organism Providencia rettgeri strain 12105 isolate P12105

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NTP67_RS21340 Protein ID WP_225833099.1
Coordinates 4574029..4574742 (-) Length 238 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NTP67_RS21345 Protein ID WP_264403986.1
Coordinates 4574782..4575039 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP67_RS21330 (NTP67_21330) 4569978..4573025 - 3048 WP_282551101.1 formate dehydrogenase-N subunit alpha -
NTP67_RS21335 (NTP67_21335) 4573202..4574032 + 831 WP_166686683.1 formate dehydrogenase accessory sulfurtransferase FdhD -
NTP67_RS21340 (NTP67_21340) 4574029..4574742 - 714 WP_225833099.1 HipA domain-containing protein Toxin
NTP67_RS21345 (NTP67_21345) 4574782..4575039 - 258 WP_264403986.1 helix-turn-helix domain-containing protein Antitoxin
NTP67_RS21350 (NTP67_21350) 4575195..4575959 - 765 WP_042846773.1 hypothetical protein -
NTP67_RS21355 (NTP67_21355) 4576090..4577454 - 1365 WP_042846829.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
NTP67_RS21360 (NTP67_21360) 4577582..4579231 - 1650 WP_042846774.1 membrane protein insertase YidC -
NTP67_RS21365 (NTP67_21365) 4579234..4579494 - 261 WP_042846775.1 membrane protein insertion efficiency factor YidD -
NTP67_RS21370 (NTP67_21370) 4579458..4579817 - 360 WP_072035181.1 ribonuclease P protein component -
NTP67_RS21375 (NTP67_21375) 4579839..4579982 - 144 WP_042846776.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(4-200)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-61)


Sequences

Toxin        


Download         Length: 238 a.a.        Molecular weight: 27212.28 Da        Isoelectric Point: 8.0790

>T262197 WP_225833099.1 NZ_CP109846:c4574742-4574029 [Providencia rettgeri]
VTLFAQVLGLISLNDVPHSFILNVGEIKALAVERFERKYSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNY
LLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFIEPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRE
MKYNIEQIFPRHFFATAKEVGFDRTEMEKILIEFDEQMESVITKVREQLPTNFPKHIADSILSGLHHKAARLKKGWD

Download         Length: 714 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9644.77 Da        Isoelectric Point: 9.7270

>AT262197 WP_264403986.1 NZ_CP109846:c4575039-4574782 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSNSNSNSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References