Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1597426..1598083 Replicon chromosome
Accession NZ_CP109846
Organism Providencia rettgeri strain 12105 isolate P12105

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag NTP67_RS07075 Protein ID WP_042845040.1
Coordinates 1597673..1598083 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag NTP67_RS07070 Protein ID WP_042845042.1
Coordinates 1597426..1597692 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP67_RS07055 (NTP67_07055) 1594504..1595394 - 891 WP_226693718.1 hypothetical protein -
NTP67_RS07060 (NTP67_07060) 1595555..1596175 - 621 WP_042845046.1 HD domain-containing protein -
NTP67_RS07065 (NTP67_07065) 1596187..1597176 - 990 WP_129466207.1 tRNA-modifying protein YgfZ -
NTP67_RS07070 (NTP67_07070) 1597426..1597692 + 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
NTP67_RS07075 (NTP67_07075) 1597673..1598083 + 411 WP_042845040.1 protein YgfX Toxin
NTP67_RS07080 (NTP67_07080) 1598137..1598655 - 519 WP_042845038.1 flavodoxin FldB -
NTP67_RS07085 (NTP67_07085) 1598773..1599675 + 903 WP_129466206.1 site-specific tyrosine recombinase XerD -
NTP67_RS07090 (NTP67_07090) 1599697..1600401 + 705 WP_264403667.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NTP67_RS07095 (NTP67_07095) 1600411..1602144 + 1734 WP_264403668.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T262194 WP_042845040.1 NZ_CP109846:1597673-1598083 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT262194 WP_042845042.1 NZ_CP109846:1597426-1597692 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References