Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 934240..934886 Replicon chromosome
Accession NZ_CP109846
Organism Providencia rettgeri strain 12105 isolate P12105

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag NTP67_RS04155 Protein ID WP_042846891.1
Coordinates 934240..934443 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag NTP67_RS04160 Protein ID WP_042846890.1
Coordinates 934518..934886 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTP67_RS04130 (NTP67_04130) 930319..930657 + 339 WP_042846895.1 P-II family nitrogen regulator -
NTP67_RS04135 (NTP67_04135) 930707..931951 + 1245 WP_230233526.1 ammonium transporter AmtB -
NTP67_RS04140 (NTP67_04140) 932092..932958 - 867 WP_042846893.1 acyl-CoA thioesterase II -
NTP67_RS04145 (NTP67_04145) 933198..933656 + 459 WP_042846892.1 YbaY family lipoprotein -
NTP67_RS04155 (NTP67_04155) 934240..934443 - 204 WP_042846891.1 HHA domain-containing protein Toxin
NTP67_RS04160 (NTP67_04160) 934518..934886 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
NTP67_RS04165 (NTP67_04165) 935416..936786 - 1371 WP_048608373.1 murein transglycosylase D -
NTP67_RS04170 (NTP67_04170) 936868..937620 - 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
NTP67_RS04175 (NTP67_04175) 937654..938388 + 735 WP_042846887.1 methyltransferase domain-containing protein -
NTP67_RS04180 (NTP67_04180) 938385..938855 - 471 WP_042846886.1 ribonuclease HI -
NTP67_RS04185 (NTP67_04185) 938910..939671 + 762 WP_042846885.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T262193 WP_042846891.1 NZ_CP109846:c934443-934240 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT262193 WP_042846890.1 NZ_CP109846:c934886-934518 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References