262191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4764465..4765723 Replicon chromosome
Accession NZ_CP109845
Organism Pseudomonas aeruginosa strain PALA33

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA33_RS22220 Protein ID WP_003112528.1
Coordinates 4764465..4765220 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA33_RS22225 Protein ID WP_003086329.1
Coordinates 4765355..4765723 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA33_RS22210 (PALA33_04410) 4759638..4762181 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA33_RS22215 (PALA33_04411) 4762336..4763697 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA33_RS22220 (PALA33_04412) 4764465..4765220 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA33_RS22225 (PALA33_04413) 4765355..4765723 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA33_RS22230 (PALA33_04414) 4765796..4767082 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA33_RS22235 (PALA33_04415) 4767138..4768727 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA33_RS22240 (PALA33_04416) 4768806..4769282 + 477 WP_003112531.1 hypothetical protein -
PALA33_RS22245 4769285..4769560 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T262191 WP_003112528.1 NZ_CP109845:c4765220-4764465 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262191 WP_003086329.1 NZ_CP109845:c4765723-4765355 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References