262189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2872035..2873077 Replicon chromosome
Accession NZ_CP109845
Organism Pseudomonas aeruginosa strain PALA33

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA33_RS13650 Protein ID WP_003050248.1
Coordinates 2872502..2873077 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA33_RS13645 Protein ID WP_003050245.1
Coordinates 2872035..2872505 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA33_RS13610 (PALA33_02690) 2867426..2868844 - 1419 WP_023087297.1 TIGR03752 family integrating conjugative element protein -
PALA33_RS13615 (PALA33_02691) 2868834..2869745 - 912 WP_023087298.1 TIGR03749 family integrating conjugative element protein -
PALA33_RS13620 (PALA33_02692) 2869742..2870434 - 693 WP_023087299.1 TIGR03746 family integrating conjugative element protein -
PALA33_RS13625 (PALA33_02693) 2870431..2870829 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA33_RS13630 (PALA33_02694) 2870842..2871201 - 360 WP_021195311.1 TIGR03745 family integrating conjugative element membrane protein -
PALA33_RS13635 (PALA33_02695) 2871218..2871451 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA33_RS13640 (PALA33_02696) 2871448..2871831 - 384 WP_023087300.1 RAQPRD family integrative conjugative element protein -
PALA33_RS13645 (PALA33_02697) 2872035..2872505 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA33_RS13650 (PALA33_02698) 2872502..2873077 + 576 WP_003050248.1 PIN domain-containing protein Toxin
PALA33_RS13655 (PALA33_02699) 2873095..2874009 + 915 WP_023087301.1 AAA family ATPase -
PALA33_RS13660 (PALA33_02700) 2874006..2874476 + 471 WP_023087302.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA33_RS13665 (PALA33_02701) 2874473..2874973 + 501 WP_003050262.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA33_RS13670 (PALA33_02702) 2874973..2875875 + 903 WP_023087303.1 CBASS oligonucleotide cyclase -
PALA33_RS13675 (PALA33_02703) 2875912..2876637 + 726 WP_023087304.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2803349..2918565 115216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21630.76 Da        Isoelectric Point: 5.6130

>T262189 WP_003050248.1 NZ_CP109845:2872502-2873077 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT262189 WP_003050245.1 NZ_CP109845:2872035-2872505 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References