Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1981340..1982848 Replicon chromosome
Accession NZ_CP109845
Organism Pseudomonas aeruginosa strain PALA33

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA33_RS09110 Protein ID WP_003119682.1
Coordinates 1981340..1981927 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7M2ZM82
Locus tag PALA33_RS09115 Protein ID WP_023087137.1
Coordinates 1981994..1982848 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA33_RS09105 (PALA33_01802) 1977595..1981074 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA33_RS09110 (PALA33_01803) 1981340..1981927 + 588 WP_003119682.1 GNAT family protein Toxin
PALA33_RS09115 (PALA33_01804) 1981994..1982848 + 855 WP_023087137.1 AraC family transcriptional regulator Antitoxin
PALA33_RS09120 (PALA33_01805) 1982945..1985110 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
PALA33_RS09125 (PALA33_01806) 1985285..1987159 + 1875 WP_003117607.1 MFS transporter -
PALA33_RS09130 (PALA33_01807) 1987220..1987429 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262187 WP_003119682.1 NZ_CP109845:1981340-1981927 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31925.22 Da        Isoelectric Point: 7.5295

>AT262187 WP_023087137.1 NZ_CP109845:1981994-1982848 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHSGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2ZM82

References