Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4564165..4565423 Replicon chromosome
Accession NZ_CP109844
Organism Pseudomonas aeruginosa strain PALA32

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA32_RS21155 Protein ID WP_003112528.1
Coordinates 4564165..4564920 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA32_RS21160 Protein ID WP_003086329.1
Coordinates 4565055..4565423 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA32_RS21145 (PALA32_04188) 4559338..4561881 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA32_RS21150 (PALA32_04189) 4562036..4563397 - 1362 WP_079391499.1 DNA recombination protein RmuC -
PALA32_RS21155 (PALA32_04190) 4564165..4564920 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA32_RS21160 (PALA32_04191) 4565055..4565423 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA32_RS21165 (PALA32_04192) 4565496..4566782 - 1287 WP_023103369.1 FAD-binding oxidoreductase -
PALA32_RS21170 (PALA32_04193) 4566838..4568427 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA32_RS21175 (PALA32_04194) 4568506..4568982 + 477 WP_003140638.1 hypothetical protein -
PALA32_RS21180 4568985..4569260 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T262184 WP_003112528.1 NZ_CP109844:c4564920-4564165 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262184 WP_003086329.1 NZ_CP109844:c4565423-4565055 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References