262181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1678754..1680449 Replicon chromosome
Accession NZ_CP109844
Organism Pseudomonas aeruginosa strain PALA32

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA32_RS07995 Protein ID WP_003112901.1
Coordinates 1678754..1679623 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA32_RS08000 Protein ID WP_003112902.1
Coordinates 1679616..1680449 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA32_RS07970 (PALA32_01573) 1674762..1675613 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA32_RS07975 (PALA32_01574) 1675654..1676661 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
PALA32_RS07980 (PALA32_01575) 1676658..1677434 + 777 WP_003112898.1 ABC transporter permease -
PALA32_RS07985 (PALA32_01576) 1677440..1678201 + 762 WP_003112899.1 SDR family oxidoreductase -
PALA32_RS07990 (PALA32_01577) 1678215..1678745 + 531 WP_003112900.1 cupin domain-containing protein -
PALA32_RS07995 (PALA32_01578) 1678754..1679623 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA32_RS08000 (PALA32_01579) 1679616..1680449 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA32_RS08005 (PALA32_01580) 1680436..1681233 + 798 WP_017001845.1 SDR family oxidoreductase -
PALA32_RS08010 (PALA32_01581) 1681226..1682908 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA32_RS08015 (PALA32_01582) 1682919..1683722 + 804 WP_003453564.1 aspartate dehydrogenase -
PALA32_RS08020 (PALA32_01583) 1683734..1685218 + 1485 WP_017001843.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T262181 WP_003112901.1 NZ_CP109844:1678754-1679623 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT262181 WP_003112902.1 NZ_CP109844:1679616-1680449 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References