Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144927..145432 Replicon chromosome
Accession NZ_CP109844
Organism Pseudomonas aeruginosa strain PALA32

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PALA32_RS00665 Protein ID WP_003121619.1
Coordinates 144927..145208 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PALA32_RS00670 Protein ID WP_003112628.1
Coordinates 145205..145432 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA32_RS00640 (PALA32_00124) 140178..141527 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA32_RS00645 (PALA32_00125) 141576..142262 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA32_RS00650 (PALA32_00126) 142363..143097 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA32_RS00655 (PALA32_00127) 143277..143687 + 411 WP_003101225.1 aegerolysin family protein -
PALA32_RS00660 (PALA32_00128) 143719..144627 - 909 WP_016561475.1 LysR family transcriptional regulator -
PALA32_RS00665 (PALA32_00129) 144927..145208 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PALA32_RS00670 (PALA32_00130) 145205..145432 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PALA32_RS00675 (PALA32_00131) 145608..146228 - 621 WP_034063665.1 hypothetical protein -
PALA32_RS00680 (PALA32_00132) 146329..146829 + 501 WP_023107528.1 LEA type 2 family protein -
PALA32_RS00685 (PALA32_00133) 146902..147243 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA32_RS00690 (PALA32_00134) 147325..148752 - 1428 WP_003083784.1 GABA permease -
PALA32_RS00695 (PALA32_00135) 148921..150414 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T262180 WP_003121619.1 NZ_CP109844:c145208-144927 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T262180 NZ_CP109844:c145208-144927 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT262180 WP_003112628.1 NZ_CP109844:c145432-145205 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT262180 NZ_CP109844:c145432-145205 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References