Detailed information of TA system TA026218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3667038..3667655
• Replicon: chromosome
• Accession: NC_017047
• Organism: Rahnella aquatilis HX2

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: H8NYI7
• Locus tag: Q7S_RS16635
• Protein ID: WP_013576617.1
• Coordinates: 3667452..3667655 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: H8NYI6
• Locus tag: Q7S_RS16630
• Protein ID: WP_013576616.1
• Coordinates: 3667038..3667406 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q7S_RS16600	3663028..3663282	+	255	WP_013576610.1	type B 50S ribosomal protein L31	-
Q7S_RS16605	3663303..3663443	+	141	WP_013576611.1	type B 50S ribosomal protein L36	-
Q7S_RS16610	3663568..3664446	-	879	WP_013576612.1	metal ABC transporter substrate-binding protein	-
Q7S_RS16615	3664490..3665347	-	858	WP_013576613.1	metal ABC transporter permease	-
Q7S_RS16620	3665344..3666072	-	729	WP_173362112.1	ABC transporter ATP-binding protein	-
Q7S_RS16625	3666455..3666808	+	354	WP_013576615.1	hypothetical protein	-
Q7S_RS16630	3667038..3667406	+	369	WP_013576616.1	Hha toxicity modulator TomB	Antitoxin
Q7S_RS16635	3667452..3667655	+	204	WP_013576617.1	hemolysin expression modulator Hha	Toxin
Q7S_RS16640	3667731..3668687	-	957	WP_013576618.1	LysR family transcriptional regulator	-
Q7S_RS16645	3668827..3670614	+	1788	WP_013576619.1	adenine deaminase	-
Q7S_RS16650	3670691..3672040	+	1350	WP_013576620.1	NCS2 family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8114.45 Da
• Isoelectric Point: 6.9764

>T26218 WP_013576617.1 NC_017047:3667452-3667655 [Rahnella aquatilis HX2]
MNKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Nucleotide

• Length: 204 bp

>T26218 NC_017047:3667452-3667655 [Rahnella aquatilis HX2]
ATGAACAAAATCGACTATTTGATGCGTTTACGAAAATGCACCACTATCGATACACTTGAACGTGTTATTGAAAAAAATAA
GTACGAACTTTCCGACGACGAGCTGGAATTGTTTTACTCGGCAGCTGACCATCGTTTAGCGGAGCTAACGATGAACAAGT
TGTACGATAAAATCCCGGTATCAGTCTGGAAATTTGTACGCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14391.15 Da
• Isoelectric Point: 4.7281

>AT26218 WP_013576616.1 NC_017047:3667038-3667406 [Rahnella aquatilis HX2]
MDEYSPKRHDIAQLRYLNEMLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYPDDNHLSDLVEEYL
DDTYTLFSNYGINDSDLRQWQKTKKRLFRMFSGDYICTLMKT

Nucleotide

• Length: 369 bp

>AT26218 NC_017047:3667038-3667406 [Rahnella aquatilis HX2]
ATGGATGAGTACTCGCCTAAGCGGCACGATATCGCTCAGTTACGCTACCTGAATGAAATGCTGTATGATGAAGGGATTGC
GACACTGGGTGACAGTCATCATGGTTGGGTTAACGATCCGACTTCGGCTGTTAACTTGCAGCTCAATGAACTGATTGAGC
ACATTGCATCCTTTGTGATGAGTTTTAAAATTAAGTATCCAGACGATAACCATTTAAGTGATCTGGTTGAAGAGTATCTG
GATGATACCTACACGCTGTTCAGTAATTATGGAATTAACGATTCTGATTTACGCCAATGGCAAAAGACCAAGAAGCGGTT
ATTCAGAATGTTCTCAGGGGACTACATCTGTACCCTAATGAAGACTTGA

Structures

Toxin

• AlphaFold DB: H8NYI7

Antitoxin

• AlphaFold DB: H8NYI6