262178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4669691..4670949 Replicon chromosome
Accession NZ_CP109843
Organism Pseudomonas aeruginosa strain PALA29

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA29_RS22215 Protein ID WP_023114076.1
Coordinates 4669691..4670446 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA29_RS22220 Protein ID WP_003086329.1
Coordinates 4670581..4670949 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA29_RS22205 (PALA29_04392) 4664864..4667407 + 2544 WP_009315399.1 acyl-homoserine-lactone acylase QuiP -
PALA29_RS22210 (PALA29_04393) 4667562..4668923 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA29_RS22215 (PALA29_04394) 4669691..4670446 - 756 WP_023114076.1 RES family NAD+ phosphorylase Toxin
PALA29_RS22220 (PALA29_04395) 4670581..4670949 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA29_RS22225 (PALA29_04396) 4671022..4672308 - 1287 WP_003449000.1 FAD-binding oxidoreductase -
PALA29_RS22230 (PALA29_04397) 4672364..4673953 - 1590 WP_073659974.1 aldehyde dehydrogenase family protein -
PALA29_RS22235 (PALA29_04398) 4674032..4674508 + 477 WP_003134036.1 elongation factor GreAB -
PALA29_RS22240 4674511..4674786 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28309.54 Da        Isoelectric Point: 8.3428

>T262178 WP_023114076.1 NZ_CP109843:c4670446-4669691 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWKL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262178 WP_003086329.1 NZ_CP109843:c4670949-4670581 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References