262176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1943751..1945259 Replicon chromosome
Accession NZ_CP109843
Organism Pseudomonas aeruginosa strain PALA29

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA29_RS09260 Protein ID WP_003119682.1
Coordinates 1943751..1944338 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PALA29_RS09265 Protein ID WP_003091607.1
Coordinates 1944405..1945259 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA29_RS09255 (PALA29_01826) 1940006..1943485 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA29_RS09260 (PALA29_01827) 1943751..1944338 + 588 WP_003119682.1 GNAT family protein Toxin
PALA29_RS09265 (PALA29_01828) 1944405..1945259 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PALA29_RS09270 (PALA29_01829) 1945356..1947521 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
PALA29_RS09275 (PALA29_01830) 1947696..1949570 + 1875 WP_023114549.1 MFS transporter -
PALA29_RS09280 (PALA29_01831) 1949631..1949840 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262176 WP_003119682.1 NZ_CP109843:1943751-1944338 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT262176 WP_003091607.1 NZ_CP109843:1944405-1945259 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References