Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148138..148643 Replicon chromosome
Accession NZ_CP109843
Organism Pseudomonas aeruginosa strain PALA29

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PALA29_RS00680 Protein ID WP_023114790.1
Coordinates 148138..148419 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA29_RS00685 Protein ID WP_003083775.1
Coordinates 148416..148643 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA29_RS00655 (PALA29_00123) 143389..144738 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA29_RS00660 (PALA29_00124) 144787..145473 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA29_RS00665 (PALA29_00125) 145574..146308 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA29_RS00670 (PALA29_00126) 146488..146898 + 411 WP_003101225.1 aegerolysin family protein -
PALA29_RS00675 (PALA29_00127) 146930..147838 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA29_RS00680 (PALA29_00128) 148138..148419 - 282 WP_023114790.1 type II toxin-antitoxin system toxin ParE Toxin
PALA29_RS00685 (PALA29_00129) 148416..148643 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA29_RS00690 (PALA29_00130) 148819..149439 - 621 WP_003101226.1 hypothetical protein -
PALA29_RS00695 (PALA29_00131) 149540..150040 + 501 WP_003101228.1 LEA type 2 family protein -
PALA29_RS00700 (PALA29_00132) 150113..150454 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA29_RS00705 (PALA29_00133) 150536..151963 - 1428 WP_003083784.1 GABA permease -
PALA29_RS00710 (PALA29_00134) 152132..153625 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10464.21 Da        Isoelectric Point: 10.0014

>T262174 WP_023114790.1 NZ_CP109843:c148419-148138 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT262174 WP_003083775.1 NZ_CP109843:c148643-148416 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References