Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 495006..495577 Replicon chromosome
Accession NZ_CP109839
Organism Enterococcus faecium strain T17-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OKL57_RS02685 Protein ID WP_142652303.1
Coordinates 495236..495577 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag OKL57_RS02680 Protein ID WP_002323011.1
Coordinates 495006..495236 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKL57_RS02655 (OKL57_02655) 490487..491815 + 1329 WP_002327434.1 FAD-containing oxidoreductase -
OKL57_RS02660 (OKL57_02660) 491837..492463 + 627 WP_002286816.1 cysteine hydrolase -
OKL57_RS02665 (OKL57_02665) 492646..493227 + 582 WP_002327433.1 TetR/AcrR family transcriptional regulator -
OKL57_RS02670 (OKL57_02670) 493592..494167 + 576 WP_002352505.1 SOS response-associated peptidase family protein -
OKL57_RS02675 (OKL57_02675) 494372..494710 - 339 WP_002306002.1 hypothetical protein -
OKL57_RS02680 (OKL57_02680) 495006..495236 + 231 WP_002323011.1 hypothetical protein Antitoxin
OKL57_RS02685 (OKL57_02685) 495236..495577 + 342 WP_142652303.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OKL57_RS02690 (OKL57_02690) 496427..496612 + 186 WP_002304207.1 hypothetical protein -
OKL57_RS02695 (OKL57_02695) 496882..498044 + 1163 WP_086956687.1 IS3 family transposase -
OKL57_RS02700 (OKL57_02700) 498166..498408 + 243 Protein_476 LPXTG cell wall anchor domain-containing protein -
OKL57_RS02705 (OKL57_02705) 498482..499378 + 897 WP_002352497.1 class C sortase -
OKL57_RS02710 (OKL57_02710) 499559..500233 + 675 WP_002291233.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13316.70 Da        Isoelectric Point: 9.9044

>T262170 WP_142652303.1 NZ_CP109839:495236-495577 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFEPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT262170 WP_002323011.1 NZ_CP109839:495006-495236 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References