Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 216060..216589 Replicon chromosome
Accession NZ_CP109839
Organism Enterococcus faecium strain T17-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag OKL57_RS01370 Protein ID WP_002319468.1
Coordinates 216323..216589 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag OKL57_RS01365 Protein ID WP_002294199.1
Coordinates 216060..216323 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKL57_RS01355 (OKL57_01355) 213435..215258 + 1824 WP_142652152.1 APC family permease -
OKL57_RS01360 (OKL57_01360) 215400..215585 - 186 WP_002294201.1 hypothetical protein -
OKL57_RS01365 (OKL57_01365) 216060..216323 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OKL57_RS01370 (OKL57_01370) 216323..216589 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
OKL57_RS01375 (OKL57_01375) 216790..217278 + 489 WP_263751820.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OKL57_RS01380 (OKL57_01380) 217820..218473 - 654 WP_228023275.1 ABC transporter permease -
OKL57_RS01385 (OKL57_01385) 218488..219405 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
OKL57_RS01390 (OKL57_01390) 219402..220043 - 642 WP_002293405.1 ABC transporter permease -
OKL57_RS01395 (OKL57_01395) 220047..221222 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T262169 WP_002319468.1 NZ_CP109839:216323-216589 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT262169 WP_002294199.1 NZ_CP109839:216060-216323 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References