Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4668682..4669940 Replicon chromosome
Accession NZ_CP109835
Organism Pseudomonas aeruginosa strain PALA26

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag PALA26_RS21700 Protein ID WP_003140635.1
Coordinates 4668682..4669437 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA26_RS21705 Protein ID WP_003086329.1
Coordinates 4669572..4669940 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA26_RS21690 (PALA26_04290) 4663853..4666396 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PALA26_RS21695 (PALA26_04291) 4666551..4667912 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA26_RS21700 (PALA26_04292) 4668682..4669437 - 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
PALA26_RS21705 (PALA26_04293) 4669572..4669940 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA26_RS21710 (PALA26_04294) 4670013..4671299 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA26_RS21715 (PALA26_04295) 4671355..4672944 - 1590 WP_003140637.1 aldehyde dehydrogenase family protein -
PALA26_RS21720 (PALA26_04296) 4673023..4673499 + 477 WP_003140638.1 hypothetical protein -
PALA26_RS21725 (PALA26_04297) 4673502..4673777 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T262163 WP_003140635.1 NZ_CP109835:c4669437-4668682 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262163 WP_003086329.1 NZ_CP109835:c4669940-4669572 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References