262162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3718794..3720014 Replicon chromosome
Accession NZ_CP109835
Organism Pseudomonas aeruginosa strain PALA26

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA26_RS17245 Protein ID WP_003110488.1
Coordinates 3719436..3720014 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA26_RS17240 Protein ID WP_003088112.1
Coordinates 3718794..3719348 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA26_RS17215 (PALA26_03401) 3714362..3714913 + 552 WP_003139878.1 XRE family transcriptional regulator -
PALA26_RS17220 (PALA26_03402) 3714910..3715308 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA26_RS17225 (PALA26_03403) 3715321..3715644 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA26_RS17230 (PALA26_03404) 3715975..3716436 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA26_RS17235 (PALA26_03405) 3716441..3718636 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA26_RS17240 (PALA26_03406) 3718794..3719348 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA26_RS17245 (PALA26_03407) 3719436..3720014 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA26_RS17250 (PALA26_03408) 3720123..3721310 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA26_RS17255 (PALA26_03409) 3721300..3723471 - 2172 WP_003139887.1 type I secretion system permease/ATPase -
PALA26_RS17260 (PALA26_03410) 3723461..3724738 - 1278 WP_003139889.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T262162 WP_003110488.1 NZ_CP109835:3719436-3720014 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262162 WP_003088112.1 NZ_CP109835:3718794-3719348 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References