Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141000..141505 Replicon chromosome
Accession NZ_CP109835
Organism Pseudomonas aeruginosa strain PALA26

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA26_RS00645 Protein ID WP_003083773.1
Coordinates 141000..141281 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag PALA26_RS00650 Protein ID WP_003137009.1
Coordinates 141278..141505 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA26_RS00620 (PALA26_00122) 136251..137600 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PALA26_RS00625 (PALA26_00123) 137649..138335 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA26_RS00630 (PALA26_00124) 138436..139170 + 735 WP_003110658.1 GntR family transcriptional regulator -
PALA26_RS00635 (PALA26_00125) 139350..139760 + 411 WP_003110659.1 aegerolysin family protein -
PALA26_RS00640 (PALA26_00126) 139792..140700 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA26_RS00645 (PALA26_00127) 141000..141281 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA26_RS00650 (PALA26_00128) 141278..141505 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
PALA26_RS00655 (PALA26_00129) 141681..142304 - 624 WP_003137011.1 hypothetical protein -
PALA26_RS00660 (PALA26_00130) 142405..142905 + 501 WP_003137013.1 LEA type 2 family protein -
PALA26_RS00665 (PALA26_00131) 142977..143318 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA26_RS00670 (PALA26_00132) 143400..144827 - 1428 WP_003137015.1 GABA permease -
PALA26_RS00675 (PALA26_00133) 144996..146489 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T262159 WP_003083773.1 NZ_CP109835:c141281-141000 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT262159 WP_003137009.1 NZ_CP109835:c141505-141278 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References