262157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4426046..4427303 Replicon chromosome
Accession NZ_CP109834
Organism Pseudomonas aeruginosa strain PALA25

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA25_RS20470 Protein ID WP_003112528.1
Coordinates 4426046..4426801 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA25_RS20475 Protein ID WP_003086329.1
Coordinates 4426935..4427303 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA25_RS20460 (PALA25_04085) 4421218..4423761 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA25_RS20465 (PALA25_04086) 4423916..4425277 - 1362 WP_095396852.1 DNA recombination protein RmuC -
PALA25_RS20470 (PALA25_04087) 4426046..4426801 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA25_RS20475 (PALA25_04088) 4426935..4427303 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA25_RS20480 (PALA25_04089) 4427376..4428662 - 1287 WP_075123144.1 FAD-binding oxidoreductase -
PALA25_RS20485 (PALA25_04090) 4428718..4430307 - 1590 WP_003145542.1 aldehyde dehydrogenase family protein -
PALA25_RS20490 (PALA25_04091) 4430386..4430862 + 477 WP_003140638.1 hypothetical protein -
PALA25_RS20495 4430865..4431140 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T262157 WP_003112528.1 NZ_CP109834:c4426801-4426046 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262157 WP_003086329.1 NZ_CP109834:c4427303-4426935 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References