Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3510234..3511455 Replicon chromosome
Accession NZ_CP109834
Organism Pseudomonas aeruginosa strain PALA25

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA25_RS16125 Protein ID WP_003102740.1
Coordinates 3510877..3511455 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA25_RS16120 Protein ID WP_003088112.1
Coordinates 3510234..3510788 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA25_RS16095 (PALA25_03212) 3505802..3506353 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA25_RS16100 (PALA25_03213) 3506350..3506748 - 399 WP_023081774.1 NADH-quinone oxidoreductase subunit A -
PALA25_RS16105 (PALA25_03214) 3506761..3507084 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA25_RS16110 (PALA25_03215) 3507415..3507876 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA25_RS16115 (PALA25_03216) 3507881..3510076 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA25_RS16120 (PALA25_03217) 3510234..3510788 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA25_RS16125 (PALA25_03218) 3510877..3511455 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA25_RS16130 (PALA25_03219) 3511564..3512751 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA25_RS16135 (PALA25_03220) 3512741..3514912 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA25_RS16140 (PALA25_03221) 3514902..3516179 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262156 WP_003102740.1 NZ_CP109834:3510877-3511455 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262156 WP_003088112.1 NZ_CP109834:3510234-3510788 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References