262152

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4505838..4507096 Replicon chromosome
Accession NZ_CP109833
Organism Pseudomonas aeruginosa strain PALA23

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA23_RS20840 Protein ID WP_003163133.1
Coordinates 4505838..4506593 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA23_RS20845 Protein ID WP_003086329.1
Coordinates 4506728..4507096 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA23_RS20830 (PALA23_04138) 4501010..4503553 + 2544 WP_031630217.1 acyl-homoserine-lactone acylase QuiP -
PALA23_RS20835 (PALA23_04139) 4503708..4505069 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA23_RS20840 (PALA23_04140) 4505838..4506593 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA23_RS20845 (PALA23_04141) 4506728..4507096 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA23_RS20850 (PALA23_04142) 4507169..4508455 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA23_RS20855 (PALA23_04143) 4508511..4510100 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA23_RS20860 (PALA23_04144) 4510178..4510654 + 477 WP_031675481.1 elongation factor GreAB -
PALA23_RS20865 4510657..4510932 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T262152 WP_003163133.1 NZ_CP109833:c4506593-4505838 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262152 WP_003086329.1 NZ_CP109833:c4507096-4506728 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References