262151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3554772..3555993 Replicon chromosome
Accession NZ_CP109833
Organism Pseudomonas aeruginosa strain PALA23

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA23_RS16400 Protein ID WP_003102740.1
Coordinates 3555415..3555993 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA23_RS16395 Protein ID WP_043089772.1
Coordinates 3554772..3555326 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA23_RS16370 (PALA23_03246) 3550340..3550891 + 552 WP_003102727.1 XRE family transcriptional regulator -
PALA23_RS16375 (PALA23_03247) 3550888..3551286 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA23_RS16380 (PALA23_03248) 3551299..3551622 - 324 WP_023119961.1 multidrug efflux SMR transporter -
PALA23_RS16385 (PALA23_03249) 3551953..3552414 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA23_RS16390 (PALA23_03250) 3552419..3554614 + 2196 WP_043089773.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA23_RS16395 (PALA23_03251) 3554772..3555326 + 555 WP_043089772.1 helix-turn-helix transcriptional regulator Antitoxin
PALA23_RS16400 (PALA23_03252) 3555415..3555993 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA23_RS16405 (PALA23_03253) 3556102..3557289 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA23_RS16410 (PALA23_03254) 3557279..3559450 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA23_RS16415 (PALA23_03255) 3559440..3560717 - 1278 WP_019396178.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262151 WP_003102740.1 NZ_CP109833:3555415-3555993 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT262151 WP_043089772.1 NZ_CP109833:3554772-3555326 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGTRLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References