262150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1871003..1872511 Replicon chromosome
Accession NZ_CP109833
Organism Pseudomonas aeruginosa strain PALA23

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA23_RS08685 Protein ID WP_003119682.1
Coordinates 1871003..1871590 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA23_RS08690 Protein ID WP_033973484.1
Coordinates 1871657..1872511 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA23_RS08680 (PALA23_01718) 1867258..1870737 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA23_RS08685 (PALA23_01719) 1871003..1871590 + 588 WP_003119682.1 GNAT family protein Toxin
PALA23_RS08690 (PALA23_01720) 1871657..1872511 + 855 WP_033973484.1 AraC family transcriptional regulator Antitoxin
PALA23_RS08695 (PALA23_01721) 1872608..1874773 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA23_RS08700 (PALA23_01722) 1874948..1876822 + 1875 WP_003117607.1 MFS transporter -
PALA23_RS08705 (PALA23_01723) 1876883..1877092 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262150 WP_003119682.1 NZ_CP109833:1871003-1871590 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31921.23 Da        Isoelectric Point: 7.5295

>AT262150 WP_033973484.1 NZ_CP109833:1871657-1872511 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVPPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References