262149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143191..143696 Replicon chromosome
Accession NZ_CP109833
Organism Pseudomonas aeruginosa strain PALA23

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA23_RS00665 Protein ID WP_003083773.1
Coordinates 143191..143472 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA23_RS00670 Protein ID WP_003083775.1
Coordinates 143469..143696 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA23_RS00640 (PALA23_00124) 138442..139791 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PALA23_RS00645 (PALA23_00125) 139840..140526 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA23_RS00650 (PALA23_00126) 140627..141361 + 735 WP_043089546.1 GntR family transcriptional regulator -
PALA23_RS00655 (PALA23_00127) 141541..141951 + 411 WP_003101225.1 aegerolysin family protein -
PALA23_RS00660 (PALA23_00128) 141983..142891 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA23_RS00665 (PALA23_00129) 143191..143472 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA23_RS00670 (PALA23_00130) 143469..143696 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA23_RS00675 (PALA23_00131) 143872..144492 - 621 WP_003101226.1 hypothetical protein -
PALA23_RS00680 (PALA23_00132) 144593..145093 + 501 WP_003101228.1 LEA type 2 family protein -
PALA23_RS00685 (PALA23_00133) 145166..145507 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA23_RS00690 (PALA23_00134) 145589..147016 - 1428 WP_003083784.1 GABA permease -
PALA23_RS00695 (PALA23_00135) 147185..148678 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T262149 WP_003083773.1 NZ_CP109833:c143472-143191 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT262149 WP_003083775.1 NZ_CP109833:c143696-143469 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References