Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3900362..3901018 Replicon chromosome
Accession NZ_CP109824
Organism Serratia marcescens strain SMBC31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OHY99_RS18865 Protein ID WP_264383682.1
Coordinates 3900362..3900751 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OHY99_RS18870 Protein ID WP_262237513.1
Coordinates 3900755..3901018 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHY99_RS18850 (OHY99_18855) 3896829..3898259 + 1431 WP_049204855.1 MFS transporter -
OHY99_RS18855 (OHY99_18860) 3898256..3899638 + 1383 WP_049204856.1 two-component system sensor histidine kinase BaeS -
OHY99_RS18860 (OHY99_18865) 3899638..3900354 + 717 WP_004941568.1 two-component system response regulator BaeR -
OHY99_RS18865 (OHY99_18870) 3900362..3900751 - 390 WP_264383682.1 type II toxin-antitoxin system VapC family toxin Toxin
OHY99_RS18870 (OHY99_18875) 3900755..3901018 - 264 WP_262237513.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OHY99_RS18875 (OHY99_18880) 3901356..3901694 + 339 WP_016926703.1 YegP family protein -
OHY99_RS18880 (OHY99_18885) 3901873..3903225 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
OHY99_RS18885 (OHY99_18890) 3903442..3903663 - 222 WP_141998673.1 hypothetical protein -
OHY99_RS18890 (OHY99_18895) 3903693..3904598 + 906 WP_043137977.1 lipid kinase YegS -
OHY99_RS18895 (OHY99_18900) 3904767..3905981 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14393.75 Da        Isoelectric Point: 9.5570

>T262139 WP_264383682.1 NZ_CP109824:c3900751-3900362 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMVRKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10092.40 Da        Isoelectric Point: 4.6702

>AT262139 WP_262237513.1 NZ_CP109824:c3901018-3900755 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDMDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References