Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1573291..1573838 Replicon chromosome
Accession NZ_CP109824
Organism Serratia marcescens strain SMBC31

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag OHY99_RS07775 Protein ID WP_049208872.1
Coordinates 1573530..1573838 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag OHY99_RS07770 Protein ID WP_025302143.1
Coordinates 1573291..1573527 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHY99_RS07755 (OHY99_07755) 1569777..1571312 + 1536 WP_089180702.1 glutathione ABC transporter substrate-binding protein GsiB -
OHY99_RS07760 (OHY99_07760) 1571365..1572285 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
OHY99_RS07765 (OHY99_07765) 1572295..1573203 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
OHY99_RS07770 (OHY99_07770) 1573291..1573527 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OHY99_RS07775 (OHY99_07775) 1573530..1573838 + 309 WP_049208872.1 CcdB family protein Toxin
OHY99_RS07780 (OHY99_07780) 1573878..1574720 - 843 WP_015377214.1 S-formylglutathione hydrolase -
OHY99_RS07785 (OHY99_07785) 1574735..1575859 - 1125 WP_043142415.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
OHY99_RS07790 (OHY99_07790) 1575890..1576810 - 921 WP_043142419.1 LysR family transcriptional regulator -
OHY99_RS07795 (OHY99_07795) 1576916..1578073 + 1158 WP_043142422.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galU / wza / galE / gnd / manB 1426204..1726001 299797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11518.35 Da        Isoelectric Point: 5.0196

>T262133 WP_049208872.1 NZ_CP109824:1573530-1573838 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAIRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT262133 WP_025302143.1 NZ_CP109824:1573291-1573527 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References