Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14159..14760 Replicon chromosome
Accession NZ_CP109824
Organism Serratia marcescens strain SMBC31

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag OHY99_RS00070 Protein ID WP_025304766.1
Coordinates 14159..14539 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag OHY99_RS00075 Protein ID WP_025304767.1
Coordinates 14539..14760 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHY99_RS00045 (OHY99_00045) 9406..10686 + 1281 WP_261456740.1 DUF3748 domain-containing protein -
OHY99_RS00050 (OHY99_00050) 10717..11064 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
OHY99_RS00055 (OHY99_00055) 11374..11787 + 414 WP_004933919.1 small heat shock chaperone IbpA -
OHY99_RS00060 (OHY99_00060) 11894..12322 + 429 WP_264383768.1 small heat shock chaperone IbpB -
OHY99_RS00065 (OHY99_00065) 12490..14148 + 1659 WP_025304765.1 putative transporter -
OHY99_RS00070 (OHY99_00070) 14159..14539 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
OHY99_RS00075 (OHY99_00075) 14539..14760 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
OHY99_RS00080 (OHY99_00080) 14835..16085 - 1251 WP_049207110.1 valine--pyruvate transaminase -
OHY99_RS00085 (OHY99_00085) 16221..18284 - 2064 WP_264383769.1 alpha-amylase -
OHY99_RS00090 (OHY99_00090) 18481..18633 + 153 WP_162837931.1 hypothetical protein -
OHY99_RS00095 (OHY99_00095) 18635..19612 - 978 WP_049204664.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T262130 WP_025304766.1 NZ_CP109824:c14539-14159 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT262130 WP_025304767.1 NZ_CP109824:c14760-14539 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References