Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 228150..228786 Replicon chromosome
Accession NZ_CP109811
Organism Mesobacillus jeotgali strain SBJS01

Toxin (Protein)


Gene name mazF Uniprot ID A0A3Q9QS43
Locus tag FOF60_RS01210 Protein ID WP_041967053.1
Coordinates 228436..228786 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W4RP20
Locus tag FOF60_RS01205 Protein ID WP_031308192.1
Coordinates 228150..228431 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOF60_RS01185 (FOF60_01185) 224291..224875 - 585 WP_192472909.1 rhomboid family intramembrane serine protease -
FOF60_RS01190 (FOF60_01190) 225020..225373 + 354 WP_192472910.1 holo-ACP synthase -
FOF60_RS01195 (FOF60_01195) 225565..226578 + 1014 WP_192472911.1 outer membrane lipoprotein carrier protein LolA -
FOF60_RS01200 (FOF60_01200) 226801..227958 + 1158 WP_192472912.1 alanine racemase -
FOF60_RS01205 (FOF60_01205) 228150..228431 + 282 WP_031308192.1 hypothetical protein Antitoxin
FOF60_RS01210 (FOF60_01210) 228436..228786 + 351 WP_041967053.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOF60_RS01215 (FOF60_01215) 230193..231026 + 834 WP_192472913.1 RsbT co-antagonist protein RsbRA -
FOF60_RS01220 (FOF60_01220) 231023..231379 + 357 WP_041967776.1 STAS domain-containing protein -
FOF60_RS01225 (FOF60_01225) 231384..231785 + 402 WP_192472914.1 anti-sigma regulatory factor -
FOF60_RS01230 (FOF60_01230) 231797..232807 + 1011 WP_192472915.1 PP2C family protein-serine/threonine phosphatase -
FOF60_RS01235 (FOF60_01235) 232866..233198 + 333 WP_192472916.1 anti-sigma factor antagonist -
FOF60_RS01240 (FOF60_01240) 233195..233668 + 474 WP_079504369.1 anti-sigma B factor RsbW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8998

>T262127 WP_041967053.1 NZ_CP109811:228436-228786 [Mesobacillus jeotgali]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10753.28 Da        Isoelectric Point: 7.2035

>AT262127 WP_031308192.1 NZ_CP109811:228150-228431 [Mesobacillus jeotgali]
VSESSATTEILVKLPQHLLSELDGFVKQENVNRSEFIYQATKMFLREKKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9QS43

Antitoxin

Source ID Structure
AlphaFold DB W4RP20

References