262126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 2524881..2525989 Replicon chromosome
Accession NZ_CP109802
Organism Enterococcus hirae strain T16-1

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag OKL56_RS11920 Protein ID WP_264378818.1
Coordinates 2524881..2525750 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OKL56_RS11925 Protein ID WP_000205227.1
Coordinates 2525765..2525989 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKL56_RS11890 (OKL56_11890) 2520230..2520529 - 300 WP_264378817.1 4'-phosphopantetheinyl transferase -
OKL56_RS11895 (OKL56_11895) 2520556..2520864 - 309 WP_002326405.1 DUF960 domain-containing protein -
OKL56_RS11900 (OKL56_11900) 2521152..2522471 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
OKL56_RS11905 (OKL56_11905) 2522699..2523226 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
OKL56_RS11910 (OKL56_11910) 2523270..2524133 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OKL56_RS11915 (OKL56_11915) 2524166..2524900 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OKL56_RS11920 (OKL56_11920) 2524881..2525750 - 870 WP_264378818.1 nucleotidyltransferase domain-containing protein Toxin
OKL56_RS11925 (OKL56_11925) 2525765..2525989 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OKL56_RS11930 (OKL56_11930) 2526132..2526218 - 87 Protein_2325 site-specific recombinase -
OKL56_RS11935 (OKL56_11935) 2526427..2527709 + 1283 Protein_2326 ISL3 family transposase -
OKL56_RS11940 (OKL56_11940) 2528018..2528821 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
OKL56_RS11945 (OKL56_11945) 2528875..2530359 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(9-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32873.61 Da        Isoelectric Point: 4.9845

>T262126 WP_264378818.1 NZ_CP109802:c2525750-2524881 [Enterococcus hirae]
MVGKVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVKEIATEINNFLNEENLNERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT262126 WP_000205227.1 NZ_CP109802:c2525989-2525765 [Enterococcus hirae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References