Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 353423..353994 Replicon chromosome
Accession NZ_CP109802
Organism Enterococcus hirae strain T16-1

Toxin (Protein)


Gene name mazF Uniprot ID I6SW09
Locus tag OKL56_RS01675 Protein ID WP_010738536.1
Coordinates 353423..353764 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I6T4M0
Locus tag OKL56_RS01680 Protein ID WP_010738535.1
Coordinates 353764..353994 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKL56_RS01655 (OKL56_01655) 348647..349648 + 1002 WP_034866081.1 aspartate-semialdehyde dehydrogenase -
OKL56_RS01660 (OKL56_01660) 349645..350994 + 1350 WP_264378875.1 aspartate kinase -
OKL56_RS01665 (OKL56_01665) 350954..352063 + 1110 WP_025480561.1 M20 family metallopeptidase -
OKL56_RS01670 (OKL56_01670) 352093..353259 + 1167 WP_081123479.1 pyridoxal phosphate-dependent aminotransferase -
OKL56_RS01675 (OKL56_01675) 353423..353764 - 342 WP_010738536.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OKL56_RS01680 (OKL56_01680) 353764..353994 - 231 WP_010738535.1 hypothetical protein Antitoxin
OKL56_RS01685 (OKL56_01685) 354454..355833 + 1380 WP_010738534.1 FAD-dependent oxidoreductase -
OKL56_RS01690 (OKL56_01690) 356014..356730 - 717 WP_264378876.1 AraC family transcriptional regulator -
OKL56_RS01695 (OKL56_01695) 356819..357499 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13101.46 Da        Isoelectric Point: 10.1962

>T262125 WP_010738536.1 NZ_CP109802:c353764-353423 [Enterococcus hirae]
VPKARNYIPKKGDIVWIDFDPSTGKEIQKRRPGLVVSRYEFNCTTMFAIICPITSTIKNLPTRYSLPKDLDTKGQVLISQ
LKSLDFKERKLKKVENLPLQDMAKIDQIIQYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8577.57 Da        Isoelectric Point: 4.1196

>AT262125 WP_010738535.1 NZ_CP109802:c353994-353764 [Enterococcus hirae]
MLITKSRLQGSSVVITLPSDNGKKPSENQEYIVVYSEDGTITLVPKIEDPFSAGQEAEYYEKDEWKDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DJ27

Antitoxin

Source ID Structure
AlphaFold DB A0A449E900

References