Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 534531..535102 Replicon chromosome
Accession NZ_CP109798
Organism Enterococcus faecium strain TF51-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OKL55_RS02605 Protein ID WP_002328559.1
Coordinates 534761..535102 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag OKL55_RS02600 Protein ID WP_002323011.1
Coordinates 534531..534761 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKL55_RS02575 (OKL55_02580) 529649..530977 + 1329 WP_002327663.1 FAD-containing oxidoreductase -
OKL55_RS02580 (OKL55_02585) 530999..531625 + 627 WP_002286816.1 cysteine hydrolase -
OKL55_RS02585 (OKL55_02590) 531808..532389 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
OKL55_RS02590 (OKL55_02595) 533121..533696 + 576 WP_002327664.1 SOS response-associated peptidase family protein -
OKL55_RS02595 (OKL55_02600) 533897..534235 - 339 WP_002327665.1 hypothetical protein -
OKL55_RS02600 (OKL55_02605) 534531..534761 + 231 WP_002323011.1 hypothetical protein Antitoxin
OKL55_RS02605 (OKL55_02610) 534761..535102 + 342 WP_002328559.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OKL55_RS02610 (OKL55_02615) 535921..537083 + 1163 WP_086956687.1 IS3 family transposase -
OKL55_RS02615 (OKL55_02620) 537214..538398 + 1185 Protein_519 SpaA isopeptide-forming pilin-related protein -
OKL55_RS02620 (OKL55_02625) 538398..539711 + 1314 WP_002328556.1 pilin N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13278.70 Da        Isoelectric Point: 10.1461

>T262123 WP_002328559.1 NZ_CP109798:534761-535102 [Enterococcus faecium]
VSGERIYIPKKGDIVWIYFDPSLGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT262123 WP_002323011.1 NZ_CP109798:534531-534761 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References