Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1345947..1346864 Replicon chromosome
Accession NZ_CP109795
Organism Bacillus velezensis strain B19

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag L0P93_RS07305 Protein ID WP_007407256.1
Coordinates 1346118..1346864 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag L0P93_RS07300 Protein ID WP_003154807.1
Coordinates 1345947..1346117 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0P93_RS07260 (1341159) 1341159..1342748 + 1590 WP_029973066.1 hypothetical protein -
L0P93_RS07265 (1342761) 1342761..1343186 + 426 WP_029973065.1 hypothetical protein -
L0P93_RS07270 (1343191) 1343191..1343388 + 198 WP_007610833.1 XkdX family protein -
L0P93_RS07275 (1343445) 1343445..1344206 + 762 WP_104678937.1 phage portal protein -
L0P93_RS07280 (1344258) 1344258..1344521 + 264 WP_021493821.1 hemolysin XhlA family protein -
L0P93_RS07285 (1344535) 1344535..1344798 + 264 WP_021493820.1 phage holin -
L0P93_RS07290 (1344812) 1344812..1345690 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
L0P93_RS07295 (1345725) 1345725..1345850 - 126 WP_003154809.1 hypothetical protein -
L0P93_RS07300 (1345947) 1345947..1346117 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
L0P93_RS07305 (1346118) 1346118..1346864 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
L0P93_RS07310 (1346968) 1346968..1347966 - 999 WP_003154805.1 inorganic phosphate transporter -
L0P93_RS07315 (1347979) 1347979..1348596 - 618 WP_003154804.1 DUF47 domain-containing protein -
L0P93_RS07320 (1348902) 1348902..1350190 - 1289 Protein_1382 amino acid permease -
L0P93_RS07325 (1350512) 1350512..1351462 + 951 WP_104678938.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T262115 WP_007407256.1 NZ_CP109795:c1346864-1346118 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT262115 WP_003154807.1 NZ_CP109795:c1346117-1345947 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References