Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4068079..4068576 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OHN14_RS20730 Protein ID WP_001173343.1
Coordinates 4068079..4068252 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OHN14_RS20735 Protein ID WP_000398619.1
Coordinates 4068280..4068576 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS20710 (4063231) 4063231..4064387 + 1157 WP_087879933.1 IS3-like element IS600 family transposase -
OHN14_RS20715 (4064433) 4064433..4064690 + 258 Protein_4049 lysine decarboxylase LdcC -
OHN14_RS20720 (4064749) 4064749..4066206 + 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
OHN14_RS20725 (4066443) 4066443..4067960 + 1518 WP_001295086.1 lysine--tRNA ligase -
OHN14_RS20730 (4068079) 4068079..4068252 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OHN14_RS20735 (4068280) 4068280..4068576 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OHN14_RS20740 (4068803) 4068803..4069075 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OHN14_RS20745 (4069087) 4069087..4069317 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
OHN14_RS20750 (4069498) 4069498..4071129 + 1632 WP_001216495.1 sensor histidine kinase -
OHN14_RS20755 (4071126) 4071126..4071845 + 720 WP_000611285.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T262110 WP_001173343.1 NZ_CP109775:c4068252-4068079 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT262110 WP_000398619.1 NZ_CP109775:c4068576-4068280 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References