262108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3381390..3382227 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag OHN14_RS17350 Protein ID WP_000227784.1
Coordinates 3381685..3382227 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag OHN14_RS17345 Protein ID WP_001297137.1
Coordinates 3381390..3381701 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS17320 (3376410) 3376410..3377357 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
OHN14_RS17325 (3377379) 3377379..3379370 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
OHN14_RS17330 (3379360) 3379360..3379974 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
OHN14_RS17335 (3379974) 3379974..3380303 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
OHN14_RS17340 (3380315) 3380315..3381205 + 891 WP_000971327.1 heme o synthase -
OHN14_RS17345 (3381390) 3381390..3381701 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
OHN14_RS17350 (3381685) 3381685..3382227 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
OHN14_RS17355 (3382283) 3382283..3382849 - 567 Protein_3393 SEL1-like repeat protein -
OHN14_RS17360 (3382883) 3382883..3383580 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
OHN14_RS17365 (3383597) 3383597..3383995 - 399 Protein_3395 SEL1-like repeat protein -
OHN14_RS17375 (3385180) 3385180..3386544 + 1365 WP_001000971.1 MFS transporter -
OHN14_RS17380 (3386672) 3386672..3387163 - 492 WP_001138904.1 nucleotide binding protein YajQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T262108 WP_000227784.1 NZ_CP109775:3381685-3382227 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT262108 WP_001297137.1 NZ_CP109775:3381390-3381701 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References