Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3343914..3344532 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OHN14_RS17155 Protein ID WP_001291435.1
Coordinates 3344314..3344532 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag OHN14_RS17150 Protein ID WP_000344804.1
Coordinates 3343914..3344288 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS17140 (3339003) 3339003..3340196 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OHN14_RS17145 (3340219) 3340219..3343368 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
OHN14_RS17150 (3343914) 3343914..3344288 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
OHN14_RS17155 (3344314) 3344314..3344532 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OHN14_RS17160 (3344703) 3344703..3345254 + 552 WP_000102564.1 maltose O-acetyltransferase -
OHN14_RS17165 (3345370) 3345370..3345840 + 471 WP_000136192.1 YlaC family protein -
OHN14_RS17170 (3346004) 3346004..3347552 + 1549 Protein_3357 cyclic-guanylate-specific phosphodiesterase PdeB -
OHN14_RS17175 (3347594) 3347594..3347947 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OHN14_RS17185 (3348326) 3348326..3348637 + 312 WP_000409911.1 MGMT family protein -
OHN14_RS17190 (3348668) 3348668..3349240 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T262107 WP_001291435.1 NZ_CP109775:3344314-3344532 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT262107 WP_000344804.1 NZ_CP109775:3343914-3344288 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References