Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 615685..616339 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OHN14_RS03220 Protein ID WP_000244777.1
Coordinates 615932..616339 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OHN14_RS03215 Protein ID WP_000354046.1
Coordinates 615685..615951 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS03190 (610854) 610854..611597 + 744 WP_000951937.1 SDR family oxidoreductase -
OHN14_RS03195 (611654) 611654..613087 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
OHN14_RS03200 (613132) 613132..613443 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
OHN14_RS03205 (613607) 613607..614266 + 660 WP_000250274.1 hemolysin III family protein -
OHN14_RS03210 (614462) 614462..615442 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
OHN14_RS03215 (615685) 615685..615951 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OHN14_RS03220 (615932) 615932..616339 + 408 WP_000244777.1 protein YgfX Toxin
OHN14_RS03225 (616379) 616379..616900 - 522 WP_001055874.1 flavodoxin FldB -
OHN14_RS03230 (617012) 617012..617908 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OHN14_RS03235 (617933) 617933..618643 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OHN14_RS03240 (618649) 618649..620382 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T262098 WP_000244777.1 NZ_CP109775:615932-616339 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262098 WP_000354046.1 NZ_CP109775:615685-615951 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References