Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 50915..51651 Replicon plasmid pYZ-58-173k
Accession NZ_CP109774
Organism Klebsiella pneumoniae strain YZ-58

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag M4Z05_RS27060 Protein ID WP_004187044.1
Coordinates 51169..51651 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag M4Z05_RS27055 Protein ID WP_003026799.1
Coordinates 50915..51181 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4Z05_RS27040 (M4Z05_27045) 46387..47781 + 1395 WP_032439652.1 cytosine permease -
M4Z05_RS27045 (M4Z05_27050) 47793..49001 + 1209 WP_032448288.1 imidazolonepropionase -
M4Z05_RS27050 (M4Z05_27055) 48994..49803 + 810 WP_023329017.1 N-formylglutamate deformylase -
M4Z05_RS27055 (M4Z05_27060) 50915..51181 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
M4Z05_RS27060 (M4Z05_27065) 51169..51651 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
M4Z05_RS27065 (M4Z05_27070) 51862..53208 + 1347 WP_077251107.1 ISNCY family transposase -
M4Z05_RS27070 (M4Z05_27075) 53368..54072 + 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
M4Z05_RS27075 (M4Z05_27080) 54349..55695 + 1347 WP_077254728.1 ISNCY family transposase -
M4Z05_RS27080 (M4Z05_27085) 55744..56142 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
M4Z05_RS27085 (M4Z05_27090) 56290..56442 - 153 WP_264370054.1 IS3 family transposase -
M4Z05_RS27090 (M4Z05_27095) 56416..56565 - 150 Protein_65 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid floR / sul2 / dfrA12 / aadA2 / tet(A) iutA / iucD / iucC / iucB / iucA 1..173418 173418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T262096 WP_004187044.1 NZ_CP109774:51169-51651 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT262096 WP_003026799.1 NZ_CP109774:50915-51181 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References