Detailed information of TA system TA262094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4903319..4905000
• Replicon: chromosome
• Accession: NZ_CP109772
• Organism: Klebsiella pneumoniae strain YZ-58

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: M4Z05_RS24385
• Protein ID: WP_004146663.1
• Coordinates: 4903319..4904236 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M4Z05_RS24390
• Protein ID: WP_004177809.1
• Coordinates: 4904242..4905000 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M4Z05_RS24365 (M4Z05_24370)	4898625..4900145	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M4Z05_RS24370 (M4Z05_24375)	4900142..4901140	+	999	WP_032420804.1	ribose ABC transporter permease	-
M4Z05_RS24375 (M4Z05_24380)	4901171..4902112	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M4Z05_RS24380 (M4Z05_24385)	4902187..4903194	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M4Z05_RS24385 (M4Z05_24390)	4903319..4904236	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M4Z05_RS24390 (M4Z05_24395)	4904242..4905000	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M4Z05_RS24395 (M4Z05_24400)	4905086..4905814	-	729	WP_023288135.1	response regulator transcription factor	-
M4Z05_RS24400 (M4Z05_24405)	4906087..4908234	+	2148	WP_264369977.1	formate dehydrogenase subunit alpha	-
M4Z05_RS24405 (M4Z05_24410)	4908464..4909150	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T262094 WP_004146663.1 NZ_CP109772:c4904236-4903319 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT262094 WP_004177809.1 NZ_CP109772:c4905000-4904242 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05