Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4747490..4748006 Replicon chromosome
Accession NZ_CP109772
Organism Klebsiella pneumoniae strain YZ-58

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M4Z05_RS23595 Protein ID WP_040216106.1
Coordinates 4747490..4747774 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M4Z05_RS23600 Protein ID WP_002886901.1
Coordinates 4747764..4748006 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4Z05_RS23570 (M4Z05_23575) 4742966..4743229 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M4Z05_RS23575 (M4Z05_23580) 4743359..4743532 + 174 WP_004222159.1 hypothetical protein -
M4Z05_RS23580 (M4Z05_23585) 4743535..4744278 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M4Z05_RS23585 (M4Z05_23590) 4744635..4746773 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M4Z05_RS23590 (M4Z05_23595) 4747022..4747486 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4Z05_RS23595 (M4Z05_23600) 4747490..4747774 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4Z05_RS23600 (M4Z05_23605) 4747764..4748006 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4Z05_RS23605 (M4Z05_23610) 4748084..4749994 - 1911 WP_032420841.1 PRD domain-containing protein -
M4Z05_RS23610 (M4Z05_23615) 4750017..4751171 - 1155 WP_004178372.1 lactonase family protein -
M4Z05_RS23615 (M4Z05_23620) 4751238..4751978 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T262093 WP_040216106.1 NZ_CP109772:c4747774-4747490 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT262093 WP_002886901.1 NZ_CP109772:c4748006-4747764 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References