Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4636327..4637137 Replicon chromosome
Accession NZ_CP109772
Organism Klebsiella pneumoniae strain YZ-58

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag M4Z05_RS23065 Protein ID WP_004178461.1
Coordinates 4636327..4636860 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M4Z05_RS23070 Protein ID WP_002887278.1
Coordinates 4636871..4637137 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4Z05_RS23060 (M4Z05_23065) 4635158..4636279 + 1122 WP_004214138.1 cupin domain-containing protein -
M4Z05_RS23065 (M4Z05_23070) 4636327..4636860 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
M4Z05_RS23070 (M4Z05_23075) 4636871..4637137 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M4Z05_RS23075 (M4Z05_23080) 4637240..4638673 - 1434 WP_032420876.1 Cu(+)/Ag(+) sensor histidine kinase -
M4Z05_RS23080 (M4Z05_23085) 4638663..4639346 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
M4Z05_RS23085 (M4Z05_23090) 4639518..4640903 + 1386 WP_032420875.1 efflux transporter outer membrane subunit -
M4Z05_RS23090 (M4Z05_23095) 4640921..4641265 + 345 WP_032420886.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T262092 WP_004178461.1 NZ_CP109772:c4636860-4636327 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT262092 WP_002887278.1 NZ_CP109772:c4637137-4636871 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References