Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846494..847151 Replicon chromosome
Accession NZ_CP109772
Organism Klebsiella pneumoniae strain YZ-58

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M4Z05_RS04700 Protein ID WP_002916310.1
Coordinates 846741..847151 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M4Z05_RS04695 Protein ID WP_002916312.1
Coordinates 846494..846760 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4Z05_RS04670 (M4Z05_04670) 841702..843135 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M4Z05_RS04675 (M4Z05_04675) 843254..843982 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M4Z05_RS04680 (M4Z05_04680) 844032..844343 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M4Z05_RS04685 (M4Z05_04685) 844507..845166 + 660 WP_002916317.1 hemolysin III family protein -
M4Z05_RS04690 (M4Z05_04690) 845265..846248 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
M4Z05_RS04695 (M4Z05_04695) 846494..846760 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M4Z05_RS04700 (M4Z05_04700) 846741..847151 + 411 WP_002916310.1 protein YgfX Toxin
M4Z05_RS04705 (M4Z05_04705) 847158..847679 - 522 WP_004144730.1 flavodoxin FldB -
M4Z05_RS04710 (M4Z05_04710) 847780..848676 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M4Z05_RS04715 (M4Z05_04715) 848699..849412 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4Z05_RS04720 (M4Z05_04720) 849418..851151 + 1734 WP_004185546.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T262083 WP_002916310.1 NZ_CP109772:846741-847151 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT262083 WP_002916312.1 NZ_CP109772:846494-846760 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References