Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 2744145..2745603 Replicon chromosome
Accession NZ_CP109761
Organism Priestia megaterium strain P-NA14

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag OHU75_RS14700 Protein ID WP_264387765.1
Coordinates 2744145..2744840 (+) Length 232 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag OHU75_RS14705 Protein ID WP_264387766.1
Coordinates 2744854..2745603 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHU75_RS14670 (OHU75_14670) 2740800..2741072 + 273 WP_264387759.1 hypothetical protein -
OHU75_RS14675 (OHU75_14675) 2741069..2741260 + 192 WP_264387760.1 hypothetical protein -
OHU75_RS14680 (OHU75_14680) 2741350..2741754 + 405 WP_264387761.1 phage holin family protein -
OHU75_RS14685 (OHU75_14685) 2741812..2742660 + 849 WP_264387762.1 N-acetylmuramoyl-L-alanine amidase -
OHU75_RS14690 (OHU75_14690) 2742730..2743740 + 1011 WP_264387763.1 LysM peptidoglycan-binding domain-containing protein -
OHU75_RS14695 (OHU75_14695) 2743831..2744055 + 225 WP_264387764.1 WYL domain-containing protein -
OHU75_RS14700 (OHU75_14700) 2744145..2744840 + 696 WP_264387765.1 hypothetical protein Toxin
OHU75_RS14705 (OHU75_14705) 2744854..2745603 + 750 WP_264387766.1 DUF4065 domain-containing protein Antitoxin
OHU75_RS14710 (OHU75_14710) 2745675..2745857 + 183 WP_264387767.1 hypothetical protein -
OHU75_RS14715 (OHU75_14715) 2746073..2746348 - 276 WP_264387768.1 hypothetical protein -
OHU75_RS14720 (OHU75_14720) 2746422..2746715 - 294 WP_264387769.1 hypothetical protein -
OHU75_RS14725 (OHU75_14725) 2746754..2746960 - 207 WP_264387770.1 helix-turn-helix transcriptional regulator -
OHU75_RS14730 (OHU75_14730) 2747245..2748603 + 1359 WP_264387771.1 FtsK/SpoIIIE domain-containing protein -
OHU75_RS14735 (OHU75_14735) 2748539..2749123 + 585 WP_264387772.1 hypothetical protein -
OHU75_RS14740 (OHU75_14740) 2749135..2749560 + 426 WP_264387773.1 hypothetical protein -
OHU75_RS14745 (OHU75_14745) 2749573..2749926 + 354 WP_264387774.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2701855..2751835 49980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(113-224)


Sequences

Toxin        


Download         Length: 232 a.a.        Molecular weight: 27276.51 Da        Isoelectric Point: 6.6276

>T262080 WP_264387765.1 NZ_CP109761:2744145-2744840 [Priestia megaterium]
MYGEELSLLLESKQQNVSYDIGRLCGVIYEIIDLHKEYTQQNINSYNLKKTSVNHILEQVDDTDTYIINKNFHTTLNKYL
SHVDRLTVDCELDYTYSDLDCRVRVKQQESIVYKIGHYHSGKSEGGRLPLNKCLNDLVGFRIVVPNFNHSCQLFEEMCGY
IGENYRIKYRDSSKGEYKATHIYFYGEGNKNYPWELQIWLPEDHANNYESHNRHKQGYKESAKIHKESFTF

Download         Length: 696 bp

>T262080 NZ_CP109761:2744145-2744840 [Priestia megaterium]
TTGTATGGAGAAGAATTGAGTCTTTTGTTGGAAAGCAAACAGCAAAATGTCAGTTATGATATAGGACGATTATGCGGGGT
TATATATGAGATCATCGATCTTCATAAGGAGTATACACAACAAAATATTAACAGTTATAACTTGAAAAAAACTTCGGTTA
ATCATATTTTGGAACAAGTTGATGATACTGATACATATATTATTAACAAGAACTTTCATACAACACTAAATAAATATCTG
AGTCATGTGGATAGGTTGACTGTTGATTGTGAGTTAGACTACACTTATAGCGACTTAGATTGTCGAGTTAGAGTTAAGCA
ACAAGAGTCCATTGTCTATAAAATTGGTCATTACCATAGTGGTAAATCAGAGGGCGGAAGGTTACCCTTAAACAAATGTT
TAAATGATTTGGTAGGGTTTCGGATAGTCGTACCAAACTTTAATCATAGTTGCCAGTTATTTGAGGAAATGTGTGGATAT
ATAGGAGAAAATTATAGAATTAAGTATAGAGATTCTTCAAAAGGGGAATATAAGGCTACACACATATATTTCTATGGAGA
AGGTAATAAGAATTACCCGTGGGAATTACAAATATGGTTACCAGAAGATCACGCAAATAATTATGAATCCCATAATAGAC
ATAAACAAGGGTATAAGGAGTCTGCAAAAATCCACAAAGAAAGTTTTACATTTTAA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28565.54 Da        Isoelectric Point: 6.1168

>AT262080 WP_264387766.1 NZ_CP109761:2744854-2745603 [Priestia megaterium]
MAFHFIAIMSHYIEGSRIGWHYSSEGRLDKEVINSFFSRVKKKCGEVHFGIHKLSTDSTSWKSVVEKDSFFDDVISTEDM
DMFIDYVSSDQQLSARDVAKFILSSIPVSHLKLQKLLYYCYAEFIQRTGLKLFREPIVSYKYGPVVESIFKEFTVHGSSI
IDYEEDKGFVISVDKMTAKPSFMKIANSEHGVVALDCIIDVLEQYGSKSPFELVDITHQEGGPWARVYKPGQNNIITDDH
IIQYHEFAK

Download         Length: 750 bp

>AT262080 NZ_CP109761:2744854-2745603 [Priestia megaterium]
ATGGCATTTCATTTTATAGCAATTATGAGTCATTATATTGAGGGGTCAAGAATCGGTTGGCACTACTCCAGTGAGGGAAG
ACTTGACAAAGAAGTCATTAACTCTTTCTTTAGTAGAGTAAAGAAAAAGTGTGGGGAGGTTCATTTTGGTATCCATAAAC
TATCCACAGACTCTACTTCATGGAAATCTGTAGTAGAGAAAGACTCGTTTTTTGATGATGTGATTTCTACAGAGGATATG
GATATGTTTATTGATTATGTATCAAGTGATCAACAATTATCTGCACGCGATGTAGCAAAATTTATATTATCATCTATTCC
AGTTTCACACCTTAAATTGCAAAAGCTTCTTTATTATTGCTATGCAGAATTCATTCAAAGAACAGGTTTAAAATTGTTTA
GAGAGCCGATTGTTTCATATAAATATGGTCCTGTTGTTGAAAGTATATTTAAAGAATTTACTGTTCATGGATCATCAATA
ATTGATTACGAAGAGGATAAAGGTTTTGTAATCTCTGTAGATAAAATGACGGCAAAGCCCTCTTTTATGAAGATTGCTAA
TTCAGAACACGGTGTAGTAGCTCTTGACTGTATTATAGATGTTTTAGAGCAGTATGGGTCCAAGTCACCTTTTGAATTAG
TTGATATTACACATCAAGAAGGTGGACCCTGGGCCAGAGTTTATAAACCAGGACAAAACAACATTATAACTGACGACCAC
ATAATACAGTATCATGAATTCGCTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References