262079

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 27206..28343 Replicon plasmid unnamed
Accession NZ_CP109759
Organism Enterococcus faecium strain XJ78NG

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OH471_RS12970 Protein ID WP_024417198.1
Coordinates 27480..28343 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OH471_RS12965 Protein ID WP_000301765.1
Coordinates 27206..27478 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH471_RS12940 (OH471_12940) 22673..23353 - 681 WP_002323195.1 IS6 family transposase -
OH471_RS12945 (OH471_12945) 23423..24247 + 825 Protein_30 IS1380-like element ISSsu5 family transposase -
OH471_RS12950 (OH471_12950) 24438..25925 + 1488 WP_077149152.1 type IA DNA topoisomerase -
OH471_RS12955 (OH471_12955) 26014..26910 + 897 WP_001835294.1 ParA family protein -
OH471_RS12960 (OH471_12960) 26974..27189 + 216 WP_001835296.1 peptide-binding protein -
OH471_RS12965 (OH471_12965) 27206..27478 + 273 WP_000301765.1 antitoxin Antitoxin
OH471_RS12970 (OH471_12970) 27480..28343 + 864 WP_024417198.1 zeta toxin family protein Toxin
OH471_RS12975 (OH471_12975) 28474..28878 + 405 Protein_36 molecular chaperone DnaJ -
OH471_RS12980 (OH471_12980) 29047..29643 - 597 WP_002326773.1 TetR/AcrR family transcriptional regulator -
OH471_RS12985 (OH471_12985) 29954..30835 + 882 WP_098379806.1 ABC transporter ATP-binding protein -
OH471_RS12990 (OH471_12990) 30859..32472 + 1614 WP_098379807.1 tetronasin resistance protein -
OH471_RS12995 (OH471_12995) 32544..33119 - 576 WP_230307287.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid ant(6)-Ia / lsa(E) / lnu(B) / erm(B) / tet(L) / tet(M) - 1..62460 62460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32404.02 Da        Isoelectric Point: 6.9964

>T262079 WP_024417198.1 NZ_CP109759:27480-28343 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT262079 WP_000301765.1 NZ_CP109759:27206-27478 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References