262078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 13983..15091 Replicon plasmid unnamed
Accession NZ_CP109759
Organism Enterococcus faecium strain XJ78NG

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag OH471_RS12890 Protein ID WP_000233000.1
Coordinates 14222..15091 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OH471_RS12885 Protein ID WP_000205227.1
Coordinates 13983..14207 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH471_RS12860 (OH471_12860) 9254..10416 + 1163 WP_086956687.1 IS3 family transposase -
OH471_RS12865 (OH471_12865) 10725..11051 + 327 Protein_14 DNA topoisomerase -
OH471_RS12870 (OH471_12870) 11362..11859 + 498 WP_002327635.1 DNA recombinase -
OH471_RS12875 (OH471_12875) 11860..12276 + 417 WP_000323438.1 recombinase -
OH471_RS12880 (OH471_12880) 12278..13840 + 1563 WP_000136908.1 recombinase family protein -
OH471_RS12885 (OH471_12885) 13983..14207 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OH471_RS12890 (OH471_12890) 14222..15091 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
OH471_RS12895 (OH471_12895) 15072..15806 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OH471_RS12900 (OH471_12900) 15839..16702 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OH471_RS12905 (OH471_12905) 16746..17273 + 528 WP_002294507.1 phosphoribosyltransferase family protein -
OH471_RS12910 (OH471_12910) 17405..18214 + 810 WP_002294509.1 ANT(9) family aminoglycoside nucleotidyltransferase Spw -
OH471_RS12915 (OH471_12915) 18393..18683 + 291 WP_010733534.1 hypothetical protein -
OH471_RS12920 (OH471_12920) 18734..19192 - 459 WP_002325145.1 hypothetical protein -
OH471_RS12925 (OH471_12925) 19275..19838 + 564 Protein_26 recombinase zinc beta ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid ant(6)-Ia / lsa(E) / lnu(B) / erm(B) / tet(L) / tet(M) - 1..62460 62460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T262078 WP_000233000.1 NZ_CP109759:14222-15091 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT262078 WP_000205227.1 NZ_CP109759:13983-14207 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References