262077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 481458..482029 Replicon chromosome
Accession NZ_CP109758
Organism Enterococcus faecium strain XJ78NG

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag OH471_RS02295 Protein ID WP_002286801.1
Coordinates 481688..482029 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag OH471_RS02290 Protein ID WP_002323011.1
Coordinates 481458..481688 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH471_RS02265 (OH471_02265) 476824..478155 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
OH471_RS02270 (OH471_02270) 478177..478803 + 627 WP_002286816.1 cysteine hydrolase -
OH471_RS02275 (OH471_02275) 478986..479567 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
OH471_RS02280 (OH471_02280) 480053..480628 + 576 WP_002293673.1 SOS response-associated peptidase family protein -
OH471_RS02285 (OH471_02285) 480833..481171 - 339 WP_002286804.1 hypothetical protein -
OH471_RS02290 (OH471_02290) 481458..481688 + 231 WP_002323011.1 hypothetical protein Antitoxin
OH471_RS02295 (OH471_02295) 481688..482029 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OH471_RS02300 (OH471_02300) 482879..483064 + 186 WP_002304207.1 hypothetical protein -
OH471_RS02305 (OH471_02305) 483569..483763 + 195 WP_002295146.1 hypothetical protein -
OH471_RS02310 (OH471_02310) 483954..484203 + 250 Protein_458 transposase -
OH471_RS02315 (OH471_02315) 484447..485277 - 831 Protein_459 manganese catalase family protein -
OH471_RS02320 (OH471_02320) 485485..486819 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T262077 WP_002286801.1 NZ_CP109758:481688-482029 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT262077 WP_002323011.1 NZ_CP109758:481458-481688 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References