Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3437942..3438599 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OI984_RS16875 Protein ID WP_021242050.1
Coordinates 3438189..3438599 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OI984_RS16870 Protein ID WP_006178375.1
Coordinates 3437942..3438208 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS16850 (OI984_16845) 3433376..3434809 - 1434 WP_008499715.1 6-phospho-beta-glucosidase BglA -
OI984_RS16855 (OI984_16850) 3434926..3435657 - 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
OI984_RS16860 (OI984_16855) 3435923..3436582 + 660 WP_021242052.1 hemolysin III family protein -
OI984_RS16865 (OI984_16860) 3436667..3437647 - 981 WP_045351721.1 tRNA-modifying protein YgfZ -
OI984_RS16870 (OI984_16865) 3437942..3438208 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OI984_RS16875 (OI984_16870) 3438189..3438599 + 411 WP_021242050.1 protein YgfX Toxin
OI984_RS16880 (OI984_16875) 3438606..3439127 - 522 WP_008499710.1 flavodoxin FldB -
OI984_RS16885 (OI984_16880) 3439229..3440125 + 897 WP_045351722.1 site-specific tyrosine recombinase XerD -
OI984_RS16890 (OI984_16885) 3440154..3440867 + 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OI984_RS16895 (OI984_16890) 3440873..3442606 + 1734 WP_045351724.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T262070 WP_021242050.1 NZ_CP109753:3438189-3438599 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT262070 WP_006178375.1 NZ_CP109753:3437942-3438208 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References