Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2289229..2289825 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag OI984_RS11270 Protein ID WP_023293553.1
Coordinates 2289229..2289531 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag OI984_RS11275 Protein ID WP_021242718.1
Coordinates 2289538..2289825 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS11250 (OI984_11250) 2285211..2286785 + 1575 WP_032654615.1 RNA repair transcriptional activator RtcR -
OI984_RS11255 (OI984_11255) 2286891..2287835 + 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
OI984_RS11260 (OI984_11260) 2287886..2288158 + 273 WP_014830263.1 DUF3811 domain-containing protein -
OI984_RS11265 (OI984_11265) 2288159..2289031 - 873 WP_045352872.1 23S rRNA pseudouridine(2604) synthase RluF -
OI984_RS11270 (OI984_11270) 2289229..2289531 + 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI984_RS11275 (OI984_11275) 2289538..2289825 + 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
OI984_RS11280 (OI984_11280) 2289822..2291453 - 1632 WP_008503411.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T262068 WP_023293553.1 NZ_CP109753:2289229-2289531 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT262068 WP_021242718.1 NZ_CP109753:2289538-2289825 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References